I've got both an R1 and a Hayabusa, I find the R1 comfortable for touring only at lower speeds (85 or below) anything above that the windblast gets too severe, also there is no protection from the rain, I don't have a problem with wrist ache.
The Bus is obviously more comforable at higher cruising speeds, it actually feels slower than the R1 due to better wind protection and the taller gearing taking the sting out of roll ons, and the real plus point, your feet stay dry in a shower!
As for handling, one up, obviously, the R1 is king but two up the Bus will show an R1 a clean pair of tyres - no problem. Two up the R1 understeers badly and is generally unstable and hard work.
I find the R1 easier to ride fast in the wet, it has better quality suspention, far better fueling and less weight conspiring against it, saying that the Bus is by no means bad, the only downers in the wet on the R1 is it's dangerous two up (understeer becomes terminal!) and it suffers from terrible brake lag (cured by a set of Carbon Lorraine SBK3 pads.)
I've found the brakes on the Bus to be inadequate - even one up, no such complaints on the R1 (in the dry) the tank range on the R1 is a good 30 miles less than the Bus.
I may have found the brakes on the Bus to be Ok had I not ever ridden a ThunderAce or R1, since then everything else is pants in the retardation department!