I am 310 lbs and a hair under 6'-1". been on the Busa for 6 years and it fits like a glove (did off the showroom floor actually). I have helibars with the 1" rise and rearsets (racing foot pegs that allow vertical and limited horizontal adjustment). I usually take "Harley rides", that is long 8-12 hour blasts through back roads. Their are some body size iuuses to look at though. My arms are longish (37" sleeve). My legs are very short as I have a 30" inseam. That means reaching the bars which is a problem for many. is very relaxed. I can't stand flatfooted on the bike though with my short legs, but they fold up on the pegs very comfortably and I usually run out of gas before I get uncomfortable. I think with your size foot position will be more of an issue than the bars frankly. Look up a modification called the "Buell Peg mod" to get additional leg room.
The Busa is the sportiest of the hyperbikes (a class of 3, the Busa, occasional Honda Blackbird and ZX-14). The riding position is forward and aggressive relative to most bigger bikes. You can alter this a bit with bar options but it is how the bike was designed and it is it's charm in many ways. Riding a bike like the busa is a different thing than riding a HD. On an HD it is about the social experience of the open road. The bike is designed to ask as little of the rider as possible as it's about the trip. The Busa, in the end is about the Bike as it provides unlimited excitement even if you ride it in a parking lot! But riding a sporty bike like the Busa will require muscle re-training. You ride sort of resting the weight of your torso on the abdomen, keeping the arms free of support responsibilities. This is the biggest source of discomfort ex-baggers feel on this bike transition.
Another thing I hear from a few people who have moved from HD's to Busas is that the Busa experience is less social. There aren't many Busa guys out there and you will quickly wonder how you didn't fall asleep on you old HD after you get used to the Busa. Sport bike guys tend to be young and crazy. The bagger crowd are cool rolling down the road very slowly, feet up, radio blasting (not a critism, that's good work if you can get it!). So your riding buddy options will get smaller.
I guess I would recommend you keep the bagger if you can until you settle in on the Busa or so you can ride either depending on the trip you have planned.
Hope this helps!