Need more info like the weight of the bike and rider, and the MPH that you are running. Your at the top of 4th now. The next step up in gearing needs to take you to the top of 5th, or there really is no benefit. If you have to shift into 5th going through the traps, you may actually slow down because every shift is 120 milliseconds off the gas. 16/43 or 16/44 should get you close to the top of 5th if you are currently running 152 mph. 16/43 is about the same as a 17/45 or 17/46, and there is less wear and better mechanical efficiency with a 17 tooth counter sprocket. Again, let us know what the weight and MPH is.