i would be more worried about the passenger. Might want to "break her in" with shorter rides involving less twisties. Might help you get a feel of how 2 up riding is as well and as some have already mentioned, a few things change when u ride 2 up. Good luck, be safe, and enjoy.
The Busa handles two up very well. Just take it easy on the throttle, so you don't lose your wife and if this is her first longer ride, stop every 40 miles and take a little break.