In my opinion, you will really only notice a difference between the two if you have a curvy ride; also, I am assuming that you will stay with /50's? If you were talking 55's, you would notice the bike fall into the curves much more easily - but on a straight ride you would wear out the middle of the tire more quickly. I prefer 190's on my Busa, more wheel equals goodness to me. The hardest I have ever ridden Bessie I have always maintained about a 1/4 inch chicken strips which tells me that I would be on the edge of a 180, but with a 190, I still have tire to go... Just my .02. You would get different opinions but I think on a bigger bike more tire is better. I ran 208's once and I really liked them.