I find that when im in a higher RPM and lower gear that I grip down harder to hold on, but if I am in a low RPM and higher gear, there is less tension there. You don't want to have a too relaxed grip, and you don't want to grip to tight for long periods of times either, just mix it up alittle and try not to stay in that 4,000-5,000 range by moving into a higher gear, then if you need to move fast for whatever reason you just slip it down 1 gear and give it gas, you will be out of that range and won't feel the shakes.